After you implement an iRule it is only utilized on new connections so it would be great to know how to clear any existing connections and have them re-establish.  TCP should recover so the user shouldn't be affected.  How do I clear connections to my Virtual Server?

Very easy..  just SSH into your LTM.  Do you know the IP Address attached to your Virtual Server?  You'll need the IP address.

Run the following command to clear connections to virtual server with an IP Address of 10.40.65.13

[dennis@zahslbco01:/S1-green-P:Active:In Sync] ~ # tmsh delete sys conn cs-server-addr 10.40.65.13

I typically run the same command like two-four times in a row to be sure all connections have been cleared.